Nanoglue — using nanotechnology to keep skin transplants alive
Nanoglue is a Swiss medtech start-up harnessing cutting-edge nanotechnology originally developed at Swiss Federal Laboratories for Materials Science and Technology (Empa) in St. Gallen to provide better healing for skin transplants and thus help patients recover and lower overall treatment costs.
Nanoglue takes advantage of the adhesive property of metal oxide nanoparticles, called nano-bridging. This phenomenon allows them to stick pieces of tissue, for instance skin, together. Additionally, the nanoparticles have bioactive properties that locally modify the cellular metabolism and as a result provide faster healing. For instance, silver-doping leads to antibiotic properties, ceria mitigates inflammation and the bioactive ceramic bioglass is tissue bonding, hemostatic and tissue regenerative. Hence, the Nanoglue paste covers all features needed for skin transplant survival. Nanoglue’s properties have already been proven in two in vivo as well as countless in vitro and ex vivo studies conducted by Tino Matter and his colleagues at Empa St. Gallen.
Value proposition: improving success rates and save money
The Nanoglue paste offers significant value to all major stakeholders. First, patients profit from a reduction in pain, better wound healing, shorter hospital stays, a reduced likelihood of aftertreatments and thus a reduction in overall treatment costs. Second, surgeons improve their operational success rates and have healthier patients. Third, hospitals profit from a higher success rate of their surgeries and a reduction in costs through shorter hospital stays per patient. Last, health insurance companies can also reduce costs by shortening hospital stays and reducing the likelihood of aftertreatments. Apart from the financial incentive, however, there is above all also an overarching ethical incentive to improve the health and life of patients all over the world.
Production process: simple and cost-effective
The production process uses liquid-feed flame spray pyrolysis (LF-FSP) during which metal oxide ions dissolved in a solvent are sprayed into a flame. The droplets containing the ions evaporate due to the heat and the ions oxidize to become metal oxide nanoparticles. This method is used in the industrial production of nanoparticles and is both established and scalable. Not only is this a very cost-effective process but it also allows for great freedom in the composition of the particles, enabling the secret formula of Nanoglue.
Competitive advantage: more properties at lower costs
The Nanoglue paste, unlike any other solution currently on the market, combines distinct properties and advantages in one product at lower costs. Conventional wound adhesives, for example, are based on the body’s own protein fibrin, which are expensive and sometimes trigger unpleasant immune reactions.
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